Evaluation and Comparison of Lipid Profile in Pregnancy and Preeclampsia

  • Naseema Ahmed Jan Department of Medicine, Bolan Medical Complex Hospital, Quetta
  • Raana Mahmood Department of Pharmacology, Karachi Medical and Dental College
  • Nosheen Wasi Department of Physiology, Karachi Medical and Dental College
  • Naila Ahmad Jan Department of Medicine, Sandaman Provisional Hospital, Quetta
  • Nargis Anjum Department of Physiology, Karachi Medical and Dental College
  • Huma Salahuddin Department of Physiology, Ziauddin Medical University
Keywords: dyslipidaemia, preeclampsia, lipid profile

Abstract

Objective: The objective of the study is to evaluate and compare the lipid profile in normotensive pregnancy and in pre-eclamptic pregnant women.
Methods: The study was a case-control study, conducted from January 2018 to June 2018. The sample size was 90. Participants were recruited after fulfilling the selection criteria out of which, 45 were normal pregnant females and 45 were pregnant females with Preeclampsia (PE). Participants were placed in two groups namely A and B. Group A were 45 healthy pregnant females and group B were 45 preeclamptic pregnant women. The biophysical parameters included age, weight, height and BMI. Blood pressure was recorded through standard protocols. Blood was taken for lipid profile which includes Cholesterol, Triglyceride and HDL-C, measured through enzymatic colourimetric (CHOD-PAP) method, Glycerol-3-Phosphate Oxidase Phenol Aminophenanzone (GPO-PAP) method and Cholesterol Oxidase-Phenol Aminophenazone (CHOD-PAP) method respectively, however; LDL-cholesterol was calculated through Friedewald's formula. Urinary protein was measured through URS Strips through semi-automated analyser CYBOW reader 300. Data were statistically analysed through IBMSPSS software version 20 with the help of one-way analysis of variance (ANOVA) analysis, Tukey'sHSD test, independent sample t-test and Pearson correlation analysis by considering p-values 0.05 as a significant.
Results: The results of the study revealed a significant rise in the lipid profile of pregnant women with preeclampsia than in normotensive pregnant women including cholesterol, Triglyceride, HDL-C and LDL-C.
Conclusion: The study concluded that dyslipidaemia or hyperlipidaemia in early pregnancy could be one of the reasons for developing preeclampsia in late pregnancy and the risk of being hypertensive in advanced age.

Published
2020-02-11