The Role Of IGF-I in Females Selected for Assisted Reproductive Technique (Art)

  • Huma Salahuddin Department of Physiology, Ziauddin University
  • Nargis Anjum Department of Physiology, Karachi Medical & Dental College
  • Rehana Rehman Department of Physiology, Aga Khan University Hospital
  • Sadia Rehman Department of Physiology, Bahria Medical College
  • Winay Kumar Department of Physiology, Bolan University
  • Naseema Ahmed Jan Department of Medicine, Bolan Medical Complex
Keywords: intracytoplasmic, Insulin like growth factor-1,, sperm injection, assisted reproductive technique, infertility.


Objective: To assess the role of Insulin growth factor-I (IGF-I) in females selected for assisted reproductive technique (ART).
Methods: In this cross-sectional study 133 infertile females were recruited for Intracytoplasmic sperm injection (ICSI). The antral follicle count (AFC), pre-ovulatory follicle count (PFC), total doses of follicle stimulating hormone (FSH) were estimated. IGF was measured. Successful pregnancy conception after
ICSI was confirmed by an intrauterine gestational sac with cardiac activity after embryo transfer. Receiver Operating Curve (ROC) analysis was also done to find out the area under the curve for clinically pregnant samples using IGF-I. Binary logistic regression analysis was done to estimate the odds ratio with 95% confidence interval for clinical pregnancy using IGF-I; all p-values less than 0.05 were considered significant.
Results: Study results revealed that IGF-I gave positive association with clinical pregnancy outcome, and is a more reliable predictor of clinical pregnancy. IGF-I gives 39.8% positive correlation with number of oocytes fertilized. These correlations were statistically significant with p-values less than 0.05. Area under the curve for clinical pregnancy using IGF-I, was 72.4% which reveals the importance of IGF-1 in predicting the outcome of ART.
Conclusion: Based on the results of the present study we came to the conclusion that IGF-I is a better and cheaper option and an important tool in the field of infertility.