Frequency and Pattern of Dyslipidaemia in Pakistani Females with Coronary Artery Disease
Objective: To determine the frequency and pattern of lipid abnormalities in diagnosed female patients of coronary artery disease in a tertiary care hospital of Karachi.
Methods: This cross-sectional study was conducted from January 2016 to August 2016. A total of 300 female patients of Coronary Artery Disease (CAD), diagnosed on the basis of angiography were in- cluded in the study. For detection of lipid profile abnormalities five ml of fasting venous sample of 10-
12 hours was obtained from the left median cubital vein under aseptic conditions. The blood was centrifuged for 5 minutes. Automated chemistry analyzer was used for lipid profile measurement via kits of the CYPRESS Laboratory (Langdorp, Belgium). Statistical analysis was done via SPSS version 17 and results were expressed as percentage and mean ± standard deviation.
Results: Mean age of recruited females was 51.36 ± 13.71 years. About 81.39% of patients were found with abnormal lipid profile. The frequency of low high-density lipoprotein cholesterol in studied population was 61.66%, high triglycerides 19.33% whereas; high low-density lipoprotein cholesterol was 17.33% respectively. Combined two parameter dyslipidaemia patterns was found in 41.32% fol- lowed by mixed dyslipidaemia in 19.33%, while isolated high-density lipoprotein hypocholesteraemia in 12.00% of study population.
Conclusion: We conclude that low levels of high-density lipoprotein cholesterol and hypertriglyceridemia, in both combined and isolated pattern, are more prevalent in Pakistani females with CAD.The data from the current study may increase the knowledge of the guidelines for lipid low- ering need in females.