Association of Serum Vitamin-D and Omentin-1 Levels in Post- Menopausal Female with Coronary Artery Disease

Abstract

Objective: The objective of the present study was to investigate the association between serum vitamin- D (calcidiol, D2) and omentin-1 levels in pre- and post-menopausal female patients with coronary artery disease (CAD).
Methods: This cross-sectional, case-based study was conducted in the cardiac ward of Civil Hospital Karachi from July 2016 to June 2017. Total 110 diagnosed female patients of coronary artery disease were included randomly in the study, out of which, 42 women were pre-menopausal, whereas, 68 post-menopausal. The diagnosis was based on coronary angiography. Serum Vitamin-D and omentin-1 levels were determined by using enzyme-linked immunosorbent assay (ELISA) in Dr Abdul Qadeer Khan Institute of Biotechnology and Genetic Engineering (KIBGE). Serum vitamin-D concentrations were classed as sufficient ( 30 ng/mL); deficient (10 to< 29 ng/mL); and insufficient ( <10 ng/mL). Data were analyzed by SSPS version 16.
Results: From our study, we observed significant low levels of serum vitamin-D and omentin-1 in pre and post-menopausal females of coronary artery disease, however, severe deficiency of Vitamin-D (<10 ng/L) was more associated with post-menopausal females. Vitamin-D deficiency (<30ng/L) was found in 82.72% (n=96) of CAD females, moreover; 46.36% (n=51) patients were found with severe vitamin-D deficiency placed in group I, 40.90% (n=45) patients were found with a moderate deficiency (17.09 ± 4 ng/mL) in group II, whereas only 12.72% (n=14) had optimal serum vitamin-D levels placed in group III. Serum vitamin-D (calcidiol, D2) level was associated positively with omentin-1 in CAD patients after adjustment for potential confounding variables; basal metabolic rate, waist circumference, blood pressure and lipid profile in multivariable linear regression analysis.
Conclusion: Within the limits of the study, we concluded that low levels of vitamin-D and omentin-1 are associated with both pre and post-menopausal females with prevalent coronary artery disease (CAD). Further investigations are required in different ethnic groups and populations to confirm the findings.