Developmental Defects of Teeth Triggered By the Estrogen Given During Pregnancy

Abstract

Objective: To explore the impact of Estrogen administered during pregnancy, on the development of teeth in intra-uterine life (IUL) and in the direction to assess the changes in the morphology of dentition of new born rabbits.
Methods: It was an experimental animal study which was conducted to evaluate the modifications in the morphological features of developing dentition in newborns. Female rabbits were selected having the weight of about 1.5 to 2.0 kg for trial purposes using the resource equation method. They were treated with Estrogen throughout the pregnancy phase. Offspring of these treated feminine bunnies were utilized for the trials. Three types of teeth i.e. central incisors, first premolars, and first molars were selected from both the jaws and extracted when the offsprings reached the age of three months to analyze the modifications developed in IUL, the samples were evaluated for volumetric assessment. The data was analysed using SPSS software version 21.
Results: The analysis of volumetric modifications between the dimensions of the control and the treatment groups unveiled that statistically significant difference between the dimensions of the teeth among both the sets was observed and analyzed. It revealed that maxillary central incisors, first premolars, and first molars showed the P values of 0.166, 0.782, 0.433 respectively while the mandibular teeth presented central incisors, first premolars, and first molars with P values of 0.142,0.001, 0.522 individually. However, Mandibular Premolars showed a noteworthy difference with a P-value of 0.001.
Conclusion: It was thus concluded that systemic administration of estrogen during pregnancy influenced the developing embryo and effected the morphology of growing teeth of the offsprings. Therefore, preventive measures might be taken regarding self-medication during pregnancy, which could help to evade the risk of teratogenic consequences on the newly erupting teeth of newborns.