Effect of Vitamin D in Dental Implants Osseointegration – A Randomized Controlled Trial

Abstract

Objective: To assess the impact of vitamin D supplementation on osseointegration success rates in dental implant patients at a tertiary care hospital.
Methods: The randomized control trial included patients aged 18 to 45 years, either gender with Vitamin D insufficiency undergoing dental implant procedures and had vitamin D insufficiency. Exclusion criteria was prior bone regenerative therapy, arthritis, periodontal disease, bleeding disorders, poor oral hygiene, uncontrolled hypertension and diabetes mellitus, severe vitamin D deficiency, chronic renal disease, use of proton pump inhibitors, pregnant women. This was a and patients were enrolled via non probability consecutive sampling. Participants were equally divided into two groups: Group A
received a daily oral intake of 5000 IU Vitamin D3 for 12 weeks, while Group B received a placebo (vitamin E 400mg). Osseo-integration was evaluated at three months using radiographic and clinical assessments with Ostell (ISQ). Additionally, serum Vitamin D levels were measured pre-operatively and post-operatively at 3 months interval post implant placement. Data analysis was performed using SPSS version 23.00.
Results: The median ISQ at three months was notably higher in Group A (Vitamin D supplement) compared to Group B (placebo), with values of 71 vs 65 ISQ (p=0.001). Moreover, the median Vitamin D levels at three months were significantly elevated in Group A compared to Group B (p=0.001). The mean age of the study sample was 33.71±7.84 years. The study found that vitamin D levels were significantly higher in Group A compared with Group B at three months (p=0.001) that suggesting that the supplementation was effective in elevating Vitamin D levels.
Conclusion: The study concludes that Vitamin D supplementation significantly improves osseointegration of dental implants. It emphasizes the importance of targeted vitamin D supplementation in optimizing implant success.