NADEEM BAIG, KHALID NIAZ.

ABSTRACT

A study in line with postmenopausal Osteoporosis

Objective: To investigate and quantify changes in the Bone mineral content (BMC) and Bone mineral density (BMD) between Reproductive and Postreproductive Aged Female Albino Rats, using DEXA scanner.

Setting: Deptt. of Anatomy, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi.

Methodology: 20 adult female albino rats were used in this study, divided into two groups: Group-A comprising 10 rats of post-reproductive age (15-21 months old) and group-B 10 rats of reproductive age (68 months old). On completion of experiment all the animals were sacrificed and their bones i.e femur, tibia and humerus were removed and preserved in formalin. Later on comparative analysis was made between the groups based on BMC and BMD mapped out through DEXA scanning.

Results: The quantitative measurement carried out by DEXA scanner revealed that bones of groupB were found to have relatively higher level of BMC and BMD compared to group-A.

Conclusion: The level of BMC and BMD in long bones of female albino rats was found to get declined with advancing age.

For Full text contact to:
Prof. Dr. Farah Mansuri
editor@annals-ashkmdc.org

Demonstrator, Department of Anatomy, Karachi Medical & Dental College and Abbasi Shaheed Hospital, Karachi *
Consultant Nuclear Physician, Atomic Energy Medical Center, JPMC Karachi *