MUHAMMAD IRFAN SAFI RIZVI, NARGIS ANJUM, AKBER ALI KHOJA.

ABSTRACT

Objective: To observe the effects of acute deterioration in GFR, induced by cisplatin, on the levels of serum creatinine and cystatin C and to correlate the level of serum creatinine and cystatin C among cancer patients and the controls.

Design: It is a comparative study carried out in the Department of physiology, Basic Medical Sciences Institute, Jinnah Postgraduate medical Centre, Karachi.

Subjects: Seventy subjects were included in the study. Group I comprising of cancer patients with GFR greater than 80 ml/min/1.73m2 and group II comprising of cancer patients with GFR less than 80 ml/min/1.73m2. Estimations of serum creatinine, urinary creatinine and cystatin C in all subjects were done twice, first before the start of chemotherapy with cisplatin and second before the start of second cycle.

Result: A highly significant correlation was found between the reciprocals of the levels of cystatin C and creatinine clearance as compared to a less significant Pvalue, which was found between the reciprocals of the levels of creatinine and creatinine clearance.

Conclusion: In conclusion, the results of this study emphasizes that serum cystatin C is a promising endogenous marker of GFR, and it might be of particular interest in patients with slightly decreased renal functions

For Full text contact to:
Prof. Dr. Farah Mansuri
editor@annals-ashkmdc.org

Assistant Professor, Department of Physiology, Karachi Medical and Dental, College, Karachi *
Assistant Professor Students Affairs, Karachi Medical & Dental College, Karachi *
Assistant Professor, Department of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi *