NADEEM BAIG, MANSOOR UL AZIZ, NUZHAT HASSAN, KHALID NIAZ.

ABSTRACT

Objective: To study the effects of Tamoxifen on long bones, i.e. Femur, Tibia and Humerus of Postmenopausal Aged Female Albino Rats Setting: Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi.

Specimens: Ninety bones comprising humerus, femur & tibia (30 each) Methodology: Quantitative measurement of BMC (bone mineral content) and BMD (bone mineral density) carried out by DEXA (Dual Energy X ray Absorptiometry) Scanning Device; Qualitative changes mapped out through plain radiology.

Results: Bones, i.e. Femur, Tibia & Humerus of Tamoxifen treated group were found to have relatively increased levels of BMC and BMD. X-rays revealed that bones have greater cortical density in case of tamoxifen treated group.

Conclusion: Tamoxifen helps preserving bone mass in bones of Aging Female Albino rats.

For Full text contact to:
Prof. Dr. Farah Mansuri
editor@annals-ashkmdc.org

Demonstrator, Department of Anatomy, Karachi Medical & Dental College and Abbasi Shaheed Hospital, Karachi *
BDS, MCPS, Assistant Professor, Karachi Medical & Dental College, Karachi. *
Department of Anatomy, Dow Medical College, Karachi *
Consultant Nuclear Physician, Atomic Energy Medical Center, JPMC Karachi *