SHAIKH SAJJAD AHMED, SALEEM AHMED KHARAL, MUHAMMAD SABIR,
RIZWANA BARAKZAI, SHAZIA ASAD.

ABSTRACT

Objective: To observe the pattern of antibiotic resistance in methicillin sensitive and methicillin resistant staphylococcus aureus. Materials and

Methods: Two hundred Staphylococcus aureus isolates from patients with hospital- acquired infections were collected. Methicillin resistance was determined by disc (oxacillin 1 µg) diffusion method. Sensitivity to other antimicrobial agents was determined by Kirby Baurer disc diffusion method.

Results: The methicillin resistant Staphylococcus aureus isolates were found sensitive to vancomycin (100%), fusidic acid (88.5%), chloramphenicol (80.8%) and fosfomycin (61.5%). All the isolates were highly resistant to other classes of antimicrobial agents.

Conclusion: Methicillin resistant Staphylococcus aureus shows multi-drug resistance and infections caused by these isolates are difficult to treat. However our results show that beside vancomycin; fusidic acid, chloramphenicol and fosfomycin are good choices and should be tried for the isolates showing sensitivity to these agents.

For Full text contact to:
Prof. Dr. Farah Mansuri
editor@annals-ashkmdc.org

Assistant Professor, Department of Pathology, Karachi Medical & Dental College, Karachi *
Professor & Head of Department of Microbiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi *
Quaid e Azam Medical College, Bahawalpur *
Quaid e Azam Medical College, Bahawalpur *
Mehdi A Manji Lab, Nazimabad, Karachi *