MOHAMMED AYUB MUSANI, SAEED AHMED SHAIKH, GULNAZ KHALID

ABSTRACT

Objective: To investigate the efficacy of Azithromycin 250 mg in acute sinusitis and acute otitis media.

Methodology: It is an observational study carried out on sixty patients, 30 each from acute sinusitis and acute otitis media were selected from E.NT OPD department of Karachi Meddical and Dental College and Abasi Shaheed Hospital. These all patients were treated with azithromycin 250 mg b.i.d for 3-7 day according to the severity of disease and response of the patients. Out of 30 patients with acute otitis media, 08 were having ear discharge at the time of presentation. All patients were followed for a period of 02 months to evaluate the efficacy, failure and complication of treatment.

Results: Out of 60 patients pain and fever subsided within 03 days in 40 patients(67%) and within 05 days in further 12 patients(20%). The remaining 08 patients i.e. 13% (2 with acute sinusitis and 06 with acute otitis media) did not responded to the treatment at the end of 07 days, requiring surgical intervention. Nasal discharge and obstruction was improved on 4th day in 28 patients with acute sinusitis. Ear discharge disappeared in all 08 patients with discharging ears and hearing improved on 10th day in 24 patients. No serious complication was observed in any patient regarding the disease or antibiotic therapy.

Conclusion: Azithromycin 250 mg b.i.d for 3-7 days was found highly effective in patients with acute sinusitis and acute otitis media. It has excellent antimicrobial activity against H.Influenza, Strep.Pneumonia and M.Catarrhalis. The overall clinical success rate was 87% within 05 days with failure rate of 13%.

For Full text contact to:
Prof. Dr. Farah Mansuri
annals-kmdc@gmaill.com