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| COMPARISION OF DIFFERENT CONCENTRATION OF BUPIVACAINE (0.1 %) / 0.2% WITH FENTANYL 2 MICRO GRAM/ML BY EPIDURAL INFUSION FOR LABOR ANALGESIA
SYED NURUL HAQUE, ANJUM ARA, QAMMAR MURTAZA, GULNAR ZAFEER, AFTAB IMTIAZ ABSTRACT OBJECTIVE: To evaluate the efficacy of 0.1 % Bupivacaine versus 0.2 % Bupivacaine with fentanyl 2 ug/ml via epidural for analgesia in labour. DESIGN: Randomized study. PLACE & DURATION OF STUDY: Single centre study of 80 patients conducted at gynae unit of Imam Clinic and General Hospital Karachi. from Jan 2002 to April 2005. MATERIAL AND METHODS: In a randomized study, 80 nulliparous parturients in labour had epidural analgesia initiated with 0.2% bupivacaine and fentanyl and were then randomized to receive either 0.1 % Bupivacaine with fentanyl 2ug/ml at 10m1 /hr (Group B1.n = 38) or 0.2% Bupivacaine with fentanyl 2ug/ml at 8ml/hr (group B2 n= 39) as epidural infusions. Bupivacaine 0.2% 5m1 as an epidural bolus was provided on request as Supplementary analgesia. RESULT: There were no significant differences between the visual analogue pain scores either with respect to motor or sensory block. The amount of local anaesthetic used was lower in 0.1% Bupivacaine group then in 0.2 % Bupivacaine group (P = 0.001) Side effects, patient satisfaction, labor outcome and neonatal outcome were similar in both groups. CONCLUSIONS: Epidural infusions of 0.1% Bupivacaine with fentanyl 2 ug/mI at 10-m1/ hr provided adequate analgesia in the first stage of labour. The level of analgesia was similar to that obtained using 0.2% Bupivacaine with fentanyl 2 ug/ml and with no differences with regard to sensory or motor block.
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