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| ANTAGONISM OF LEVCROMAKALIM BY GLIBENCLAMIDE (GLYBURIDE) IN THE UTERUS OF RAT IN VITRO
SAEED AHMED SHAIKH, ABDUL HAMEED KHAN, AYOOB MOOSANI, SAIFUL HAQUE, KHAIRUN NISA SAEED ABSTRACT This study was conducted in the department of Pharmacology, Shaikh Zayed, Post Graduate Medical Institute, Lahore. In the present study the Antagonistic (Inhibitory) effect of Glibenclamide (Glyburide) an oral anti-hyperglycemic agent, on relaxant effect of Levcromakalim (a Potassium Channel Opener) on the non Pregnant isolated rat uterus was studied. Twenty Five albino rats (Sprague Dawley Strain) were sacrificed. The rats were injected with diethyl stilbestrol (estrogen) intra muscularly, 24 hours before the experiments to facilitate the contractile effect of oxytocin on isolated rat uterus. The dose of oxytocin (Mean ± SEM) 4.360 ± 0.644ng was required to produce sub-maximial contraction of the uterus. The dose of Levcromakalim (Mean ± SEM) 3.041 ± 0.364ug was required to decrease / inhibit 50% contraction of uterus induced by oxytocin. In the presence of Glibenclamide, the dose of Levcromakalim was required (Mean ± SEM) 7.41 ± 0.834ug (<0.05) to reduce 50% contraction of the uterus produced by oxytocin.
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