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| SIGNIFICANCE OF HER-2/NEU ONCOPROTEIN OVER EXPRESSION
IN INVASSIVE DUCTAL BREAST CANCER
NAQVI S.Q.H., MEMON R.A., MEMON G.A., DAHRI F.J, AKHUND AA. ABSTRACT Objective: To asses the frequency of HER-2/neu Oncoprotein over expression in invasive ductal breast cancer and correlate it various prognostic parameters. Design: Cross-sectional study. Place: Department of pathology Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. Subjects & Methods: Seventy two (72) formalin fixed paraffin embed ded blocks of diagnosed invasive ductal carcinoma were retrieved and 5 p.m Results: 179 aspirates were obtained from 158 patients. The cytological diagnosis were; 78 (43.6%) reactive, 43 (24.0%) tuberculous lymphadenitis, 27 (15.1%) suppurative inflammation, 15 (8.3%) non Hodgkin's lymphoma, 05 (2.8%) Hodgkin's lymphoma, 03 (1.7%) leukemic infiltration, 02 (1.1%) cytological diagnosis uncertain, 06 (3.4%) material inadequate. 06 cytological diagnosis were false negative and one was false positive. The overall accuracy was 96%.
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