FAREEDA ISLAM, RAFEEQ ALAM KHAN, PROF. S.M.SHAMIM, TALAT MIRZA

ABSTRACT

Introduction: Entoban is a well balanced composition of medicinal herbs which includes Holarrhena antidysenterica, Berberis aristata, Aegle marmelos, Quercus infectoria, Butea Frondosa and Myrtus Communis. It is used in amoebic dysentery.

Material and Methods: The study was carried out on 27 healthy white rabbits of either sex weighing from 1800 to 2000 grams. All animals were equally divided into three groups one served as control, the other two received normal and high doses of entoban syrup. Before administration of the drug animals were acclimatized to housing conditions for 15 days. Entoban was administered in normal dose 1.14 mg/ kg and 2.29 mg/ kg high dose for a period of 60 days. The control group received normal saline equivalent to the volume of respective doses according to their body weight. Blood samples of about 7cc were collected from the animals through cardiac puncture various biochemical tests were done to consider cardiac, renal and hepatic parameters were done.

Discussion: Cardiac, renal and hepatic parameters were found to be in normal range with high dose. It determines that entoban is a safe drug. Therefore cardiac, renal, and hepatic toxicity has been ruled out.

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