*MUGHIS UDDIN AHMED, **MOTASIM AHMED, ***TAHANI NAVEED,
***Rehana M. Saadi, ****Shin Isomura, *****Yasmin Akbani

ABSTRACT

Human enteroviruses belong to the Picornaviridae family and are divided among 5 groups (poliovirus, human enterovirus A, human enterovirus B, human enterovirus C, and human enterovirus D) by molecular characteristics. These species comprise altogether 62 antigenically distinct serotypes and at least 30 additional recently described genetically distinguishable types1,4,22. Enteroviruses are non-enveloped small viruses (20-30 nm) of icosahedral symmetry. Their RNA genomes have 7.5 kb, positive sense and single strand. They are responsible for an extensive variety of diseases, although 50 to 80% of the infections are asymptomatic. They cause hepatitis, pleurodinia, stomatitis and neonatal sepsis in a significant number of patients every year. In developing countries, the poliovirus is clinically the most significant member of the genus Enteroviruses (EV) causing paralysis diseases in every 4 out of 1,000 children in school age. The non-polio enteroviruses (NPEV) are the main responsible for aseptic meningitis, myocarditis and nonspecific febrile exanthematous illnesses. Other illnesses with chronic course, such as type I diabetes mellitus, have also been associated with enterovirus infections Approximately 75% of infections by EV occur in children under 15 years of age and the attack rates are highest in children under 1 year of age1-4,22.........

For Full text contact to:
Prof. Dr. Farah Mansuri
editor@annals-ashkmdc.org

* Department of Serology & Microbiology
King Abdulaziz Hospital Al-Ahsa Saudi Arabia
** Moosa General Hospital Al-Ahsa, KSA
*** Moinia Polyclinic F.B.Area Gulberg Karachi-Pakistan
**** Department of Paediatrics,
Nagoya University, Nagoya Japan
*****Department of Paediatrics,
Abbasi Shaheed Hospital, Karachi-Pakistan.