1MUHAMMAD AKBAR MUGHAL, 2ABDUL SHAKOOR MEMON, 3BASHIR HANIF, 4NARGIS ANJUM

ABSTRACT

Objectives: (1) To compare the serum thrombomodulin levels between apparently healthy subjects and patients with myocardial infarction and unstable angina & (2) To assess, whether it may be identified as a protective marker for determining the incidence of coronary artery disease
Material and Methods: The controls and patients were taken by convenient sampling. A total of 32 control (healthy) subjects were compared with 32 consecutive patients with history of myocardial infarction, (M.I.) and 32consecutive patients with history of unstable angina (U.A.) respectively. The diagnosis of myocardial infarction (M.I.) and unstable angina was made on the basis of history, E.C.G. & Trop. I levels. Serum thrombomodulin and serum lipid profile of each subject were determined by ELISA Kit methods. One way analysis of variance (ANOVA) was conducted for comparison of serum thrombomodulin level among healthy, Myocardial infarction (M.I.) & unstable angina (U.A.) patients.
Results: Serum Thrombomodulin levels were significantly higher in controls when compared to patients of myocardial infarction and unstable angina. Serum L.D.L. cholesterol and total cholesterol levels were significantly higher in diseased group in comparison with control.
Conclusion: Inour study healthy population had increased Thrombomodulin levels as compared to patients of coronary artery disease (C.A.D.)
Key words: Thrombomodulin (TM), Myocardial Infarction, Unstable angina.

For Full text contact to:
Prof. Dr. Farah Mansuri
editor@annals-ashkmdc.org

1 Department of Physiology, Karachi Medical & Dental College & Abbasi Shaheed Hospital, Karachi.
2 Department of Physiology, BMSI, JPMC.
3 Tabba Heart Institute, Karachi
4 Department of Physiology, Karachi Medical & Dental College & Abbasi Shaheed Hospital, Karachi.