| SIGNIFICANCE OF SEROLOGICAL MONITORING FOR HEPATITIS B VIRAL INFECTION IN HEMODIALYSIS PATIENTS
1SYED MANZOOR IQBAL, 2RAZIUDDIN AHMED, 3KHURRAM JAH SIDDIQUI, 4MUKESH KUMAR, 5M. IRFAN KHAN, 6FAKHARUDDIN
ABSTRACT
Objective: To find
out the prevalence of Hepatitis B by serological monitoring in chronic
hemodialysis patients.
Material & Methods: The study was carried out in
the department of Microbiology BMSI, JPMC Karachi, from January
2010 till February 2011. Two hundred blood samples were collected
from the patients on chronic maintenance hemodialysis from the different
hospitals/ dialysis centres in Karachi. that had at least twenty
cycles of hemodialysis in tertiary care hospitals of Karachi. Blood
was collected from each patient and the test was performed according
to the standard protocol.
Result: Out of 200 patients, 51(25.5%) patients
were already vaccinated for HBV while in 149 (74.5 %) patients there
was no history of HBV vaccination. Among these 149 patients, 32
(21.47 %) showed seropositivity for HBV infections in our study.
The risk for acquiring these infections is significantly associated
with increasing duration of dialysis. Mean age of 56.7ąSD 0.68 years
with male predominance. There are only 25.5% patients who were vaccinated
against HBV infection among 200 patients.
Conclusion: The study revealed that HBV prevalence
was commonly found among dialysis patients and only quarter of them
were vaccinated. The vaccination should be mandatory in dialysis
centers to prevent and control hepatitis B in hemodialysis units.
Key word: Hemodialysis, seropositivity, HBV, vaccination.
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